Project P19 N

Mechanism of initiating autophagosome biogenesis on ER membrane

Research Group
Principal investigator
Principal investigatorDr. Alex Faesen
Max Planck Institute for
Multidisciplinary Sciences
Am Faßberg 11
D-37077 Göttingen

+49 551 201 1155 (phone)
afaesen@mpinat.mpg.de (e-mail)

mpinat.mpg.de/de/faesen
(research group)

About

Upon starvation, autophagy is dramatically upregulated and initiates the recycling of nutrients. It captures cellular targets into a specialized ab initio formed double membrane autophagosome originating from a few discrete contacts with the ER. However, the molecular mechanisms that control the initiation in space and time are unclear. We will address these questions in a reconstituted system with purified recombinant human proteins, where we aim to define the minimal machinery and identify the concepts and principles that govern this process.